Sex difference in septal neurons projecting axons to midbrain central gray in rats: A combined double retrograde tracing and ER-immunohistochemical study

Shinji Tsukahara, Korehito Yamanouchi*

*この研究の対応する著者

研究成果: Article査読

29 被引用数 (Scopus)

抄録

Sex difference in the number of neurons projecting axons from the lateral septum (LS) to the midbrain central gray (MCG) that are concerned with the lordosis-inhibiting system was investigated by injection of Fluoro-Gold (FG), a retrograde tracer, into the rostral MCG on the right side in male and female rats. Immunohistochemistry for ER-α and -β was also performed with or without combination with FG immunostaining. All animals were gonadectomized. Lordosis was observed after treatment with E2 in some animals. In the results, lordosis was rare in males, compared with females. FG-immunoreactive (ir) cells were concentrated in the intermediate LS on the right side, and its number in the females was significantly higher than that in the males. There was no sex difference in the distribution and number of ERα-ir and ERβ-ir cells in the LS. Furthermore, the number of ERs-ir cells was not influenced by E2 in either males or females. Double FG-ERβ-ir cells were less than 20% of total FG-ir cells in the LS in both males and females. These data suggest that the LS-MCG connection is sexually dimorphic but that there is no sex difference in the expression of ERs in the LS.

本文言語English
ページ(範囲)285-294
ページ数10
ジャーナルEndocrinology
143
1
DOI
出版ステータスPublished - 2002

ASJC Scopus subject areas

  • 内分泌学
  • 内分泌学、糖尿病および代謝内科学

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