TY - JOUR
T1 - Sexual function is an indicator of central arterial stiffness and arterial stiffness gradient in Japanese adult men
AU - Kumagai, Hiroshi
AU - Yoshikawa, Toru
AU - Myoenzono, Kanae
AU - Kosaki, Keisei
AU - Akazawa, Nobuhiko
AU - Asako, Zempo Miyaki
AU - Tsujimoto, Takehiko
AU - Kidokoro, Tetsuhiro
AU - Tanaka, Kiyoji
AU - Maeda, Seiji
N1 - Funding Information:
The authors acknowledge operating funds from the Ontario Mental Health Foundation and the Canadian Institutes of Health Research (CIHR) MOP 114913 to Lanctôt and Herrmann. Mazereeuw received a CIHR Training Program in Neurodegenerative Lipidomics Graduate Scholarship as well as an Ontario Graduate Scholarship. This research was supported by an operating grant from the CIHR Partners as part of the Canadian Consortium on Neurodegeneration in Aging (CCNA) (CIHR Funding Reference Number CAN 137794) (Lanctôt and Herrmann).
Publisher Copyright:
© 2018 The Authors.
PY - 2018/5/15
Y1 - 2018/5/15
N2 - Background--As arterial stiffness increases in the absence of subjective symptoms, a personal indicator that reflects increased risk of cardiovascular disease is necessary. Penile erection is regulated by vascular function, and atherosclerosis affects the penile artery earlier than it affects the coronary and carotid arteries. Therefore, we hypothesized that deterioration of erectile function could be a marker of increased risk for cardiovascular disease. To test our hypothesis, we assessed erectile function and arterial stiffness in a cross-sectional study. Methods and Results--Carotid-femoral pulse wave velocity (PWV), brachial-ankle PWV, femoral-ankle PWV, and arterial stiffness gradient (PWV ratio: carotid-femoral PWV/femoral-ankle PWV) were measured as indexes of central, systemic, and peripheral arterial stiffness and peripheral organ damage, respectively, in 317 adult men. In addition, erectile function was assessed by using the questionnaire International Index of Erectile Function 5 (a descending score indicates worsening of erectile function). The scores of male sexual function were inversely correlated with carotid-femoral PWV (rs=-0.41), brachial-ankle PWV (rs=-0.35), femoral-ankle PWV (rs=-0.19), and PWV ratio (rs=-0.33). Furthermore, multivariate linear regression analyses revealed that International Index of Erectile Function 5 scores were significantly associated with carotid-femoral PWV (β=-0.22) and PWV ratio (β=-0.25), but not with brachial-ankle PWV and femoral-ankle PWV. Conclusions--Our results indicated that erectile function is independently associated with central arterial stiffness and peripheral organ damage. These findings suggest that male sexual function could be an easily identifiable and independent marker of increased central arterial stiffness and peripheral organ damage.
AB - Background--As arterial stiffness increases in the absence of subjective symptoms, a personal indicator that reflects increased risk of cardiovascular disease is necessary. Penile erection is regulated by vascular function, and atherosclerosis affects the penile artery earlier than it affects the coronary and carotid arteries. Therefore, we hypothesized that deterioration of erectile function could be a marker of increased risk for cardiovascular disease. To test our hypothesis, we assessed erectile function and arterial stiffness in a cross-sectional study. Methods and Results--Carotid-femoral pulse wave velocity (PWV), brachial-ankle PWV, femoral-ankle PWV, and arterial stiffness gradient (PWV ratio: carotid-femoral PWV/femoral-ankle PWV) were measured as indexes of central, systemic, and peripheral arterial stiffness and peripheral organ damage, respectively, in 317 adult men. In addition, erectile function was assessed by using the questionnaire International Index of Erectile Function 5 (a descending score indicates worsening of erectile function). The scores of male sexual function were inversely correlated with carotid-femoral PWV (rs=-0.41), brachial-ankle PWV (rs=-0.35), femoral-ankle PWV (rs=-0.19), and PWV ratio (rs=-0.33). Furthermore, multivariate linear regression analyses revealed that International Index of Erectile Function 5 scores were significantly associated with carotid-femoral PWV (β=-0.22) and PWV ratio (β=-0.25), but not with brachial-ankle PWV and femoral-ankle PWV. Conclusions--Our results indicated that erectile function is independently associated with central arterial stiffness and peripheral organ damage. These findings suggest that male sexual function could be an easily identifiable and independent marker of increased central arterial stiffness and peripheral organ damage.
KW - Arterial stiffness
KW - Erectile dysfunction
KW - Predictors
KW - Sexual dysfunction
KW - Vascular function
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U2 - 10.1161/JAHA.117.007964
DO - 10.1161/JAHA.117.007964
M3 - Article
C2 - 29730645
AN - SCOPUS:85046958872
VL - 7
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
SN - 2047-9980
IS - 10
M1 - e007964
ER -