Shear stress distribution on the surface of endothelial cells during flow-induced morphological remodeling

Shuichiro Fukushima*, Hideki Fujioka, Kazuo Tanishita

*この研究の対応する著者

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Morphological remodeling of endothelial cells that was induced by blood flow is considered an adaptive response to a mechanical stimulus. To determine the mechanisms of the response, we examined how shear stress on the surface of the same group of cells changed. The surface geometry of the cells was measured by confocal laser scanning microscopy, and the shear stress distribution on the measured cell surface was determined using the flow field simulated by computational fluid dynamics. When the cells, which were polygonal without alignment at the beginning of the flow exposure, elongated and aligned in the flow direction, the mean shear stress of the cells decreased with time. However, there were some cells whose mean shear stress was increased, and the morphological change of each cell was not always adaptive. The results show the importance of interaction with surrounding cells to the adaptive response as demonstrated in the endothelial layer.

本文言語English
ページ(範囲)1275-1283
ページ数9
ジャーナルJSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing
46
4
出版ステータスPublished - 2003 12月
外部発表はい

ASJC Scopus subject areas

  • 産業および生産工学
  • 機械工学

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