Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata

Shuhei Murayama, Yasufumi Imae, Kentaro Takada, Jo Kikuchi, Yoichi Nakao, Rob W.M. Van Soest, Shigeru Okada, Shigeki Matsunaga

研究成果: Article

6 引用 (Scopus)

抜粋

Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC 50 value of 8 μg/mL each.

元の言語English
ページ(範囲)6594-6598
ページ数5
ジャーナルBioorganic and Medicinal Chemistry
19
発行部数22
DOI
出版物ステータスPublished - 2011 11 15

    フィンガープリント

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

これを引用

Murayama, S., Imae, Y., Takada, K., Kikuchi, J., Nakao, Y., Van Soest, R. W. M., Okada, S., & Matsunaga, S. (2011). Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata. Bioorganic and Medicinal Chemistry, 19(22), 6594-6598. https://doi.org/10.1016/j.bmc.2011.06.052