Short step synthesis of natural 2-arylquinolones based on iridium-catalyzed three-component coupling quinoline synthesis

Takayuki Nakajima, Takashi Inada, Isao Shimizu

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Eduline (la), graveoline (1b), and 6-methoxy-2-(4-methoxyphenyl)-1-methylquinolone (1c) were synthesized by iridium-catalyzed three-component coupling reaction. Reaction of an aniline, an aromatic aldehyde, and acetaldehyde gave the corresponding substituted quinoline. Using 1,1-dimethoxyethane instead of acetaldehyde, the three component coupling reactions were also carried out to give the quinolines in higher yields. N-Methylation of the quinolines with methyl trifrate followed by oxidation with potassium ferricianate gave the quinolones.

本文言語English
ページ(範囲)497-504
ページ数8
ジャーナルHeterocycles
69
1
出版ステータスPublished - 2006 12 1

ASJC Scopus subject areas

  • Organic Chemistry

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