Sialylglycan-modified field effect transistor for detection of charged lectin under physiological conditions

Takahiro Nakamura, Yoshihiro Sakurai, Sho Hideshima, Shigeki Kuroiwa, Tetsuya Osaka

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Determination of protein charges under physiological conditions by field effect transistors (FETs) is challenging because of the screening effect by solution counter ions. We showed that sugar-chain-modified FETs can detect proteins under physiological conditions. Protein charges are detectable on the gate interface by applying sugar chains as receptors: these sugar chains are short and highly flexible. Threshold voltage shifts caused by adsorption of SSA lectin from Sambucus sieboldiana onto sialylglycan-modified FET showed a linear relationship with SSA concentrations under physiological conditions.

本文言語English
ページ(範囲)1245-1247
ページ数3
ジャーナルChemistry Letters
39
12
DOI
出版ステータスPublished - 2010 12 13

ASJC Scopus subject areas

  • Chemistry(all)

フィンガープリント 「Sialylglycan-modified field effect transistor for detection of charged lectin under physiological conditions」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル