Signal transduction cascade shared by epidermal growth factor and platelet-derived growth factor is a major pathway for oncogenic transformation in NRK cells.

A. Masuda, S. Kizaka-Kondoh, H. Miwatani, Yasuhiko Terada, H. Nojima, H. Okayama

研究成果: Article

16 引用 (Scopus)

抄録

We have isolated two recessive, mutually complementary NRK cell mutants that are refractory to transformation by epidermal growth factor (EGF) and transforming growth factor-beta. Both mutants are defective in a signal transduction cascade shared by EGF and platelet-derived growth factor (PDGF). Analysis of the mutants suggests that transformation of NRK cells by the v-fms, v-erbB, activated erbB-2, v-ras, v-fos, v-mos, v-fes, v-src, SV40 large T, polyomavirus middle T, and human papillomavirus type 16 E6,E7 oncogenes is mediated by the EGF/PDGF signal cascade. The data also suggest that the EGF/PDGF cascade branches into mitogenic and oncogenic signals, the latter of which is required for soft agar growth and focus formation.

元の言語English
ページ(範囲)489-503
ページ数15
ジャーナルThe New biologist
4
発行部数5
出版物ステータスPublished - 1992 5
外部発表Yes

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Signal transduction
Platelet-Derived Growth Factor
Epidermal Growth Factor
Signal Transduction
Polyomavirus
Human papillomavirus 16
Oncogenes
Transforming Growth Factor beta
Refractory materials
Agar
Growth

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Signal transduction cascade shared by epidermal growth factor and platelet-derived growth factor is a major pathway for oncogenic transformation in NRK cells. / Masuda, A.; Kizaka-Kondoh, S.; Miwatani, H.; Terada, Yasuhiko; Nojima, H.; Okayama, H.

:: The New biologist, 巻 4, 番号 5, 05.1992, p. 489-503.

研究成果: Article

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AU - Masuda, A.

AU - Kizaka-Kondoh, S.

AU - Miwatani, H.

AU - Terada, Yasuhiko

AU - Nojima, H.

AU - Okayama, H.

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