Significance of plasma endothelin-1 levels in patients with systemic sclerosis

K. Yamane*, T. Miyauchi, N. Suzuki, T. Yuhara, T. Akama, H. Suzuki, H. Kashiwagi

*この研究の対応する著者

研究成果: Article査読

158 被引用数 (Scopus)

抄録

Endothelin-1 (ET-1) is a novel potent vasoconstrictor peptide discovered in the supernatant fraction of cultured endothelial cells. We measured plasma levels of ET-1 using a sensitive sandwich enzyme immunoassay. Plasma concentrations of ET-1 in 31 patients with systemic sclerosis (SSc) (1.90 + 0.47 pg/ml) were higher than those (1.31 + 0.10 pg/ml) in 25 age and sex matched healthy subjects. Patients with SSc with diffuse scleroderma had higher levels of ET-1 compared with those with limited scleroderma. Plasma ET-1 levels correlated inversely with carbon monoxide diffusing capacity (DL(co)). Measurement of plasma ET-1 levels may be useful as a predictor of prognosis of SSc.

本文言語English
ページ(範囲)1566-1571
ページ数6
ジャーナルJournal of Rheumatology
19
10
出版ステータスPublished - 1992
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • リウマチ学
  • 免疫学

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