Silicone vascular models for analysis of carotid artery stenting

Y. Okamoto, H. Inukai, H. Kobashi, H. Yamaga, T. Yagi, K. Iwasaki, R. Shiurba, M. Umezu

研究成果: Conference contribution

抄録

Carotid artery stenting (CAS) is a minimally invasive surgical treatment for stenosis that is usually due to atherosclerotic plaque. Criteria to select an optimal stent for each clinical situation are lacking, however. Here we describe a surgical simulator that predicts vascular geometries after stenting using silicone rubber models of stenotic carotid arteries. Our objective was to develop the fabrication scheme of such vascular models. Herein, four CAS vascular models, or a soft plaque, two normal, and a hard one, were fabricated. By using rapid prototyping of 3D CT angiographic data, we first made a patient-specific wax models with geometries that matched the lumen of carotid artery. Next, we fabricated a plaque model that matches patient-identical geometries. Then, we produced the each part using silicone rubber with different mechanical properties. In order to match the mechanical properties of the vessel model, pre- and post-stent geometry were compared in vivo and vitro using digital angiography. Moreover, we compared the stiffness of the vessel model by the Young's modulus. We first evaluated the mechanical properties of the vessel, and then that of the plaque. As for the former, the relationship between the expansion ratio and the stiffness parameter β was formulated by curve-fitting. We evaluated the mechanical properties of each plaque. It was found that the Young's modulus were 0.015, 0.092, 0.137, 0.503 N/m2, for the soft, normal (two cases), and hard plaque, respectively. The largest difference was about 34 times for the soft and hard one. We achieved to develop a novel fabrication scheme for the carotid artery with atherosclerotic plaque. The validated vascular model featured two distinct mechanical properties for the vessel and plaque. Such models may help surgeons develop criteria to optimize CAS in a patient-specific manner.

本文言語English
ホスト出版物のタイトル6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
ページ398-401
ページ数4
DOI
出版ステータスPublished - 2010 10 22
イベント6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech - Singapore, Singapore
継続期間: 2010 8 12010 8 6

出版物シリーズ

名前IFMBE Proceedings
31 IFMBE
ISSN(印刷版)1680-0737

Conference

Conference6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
国/地域Singapore
CitySingapore
Period10/8/110/8/6

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 生体医工学

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