Silver-Catalyzed Efficient Synthesis of Oxindoles and Pyrroloindolines via α-Aminoalkylation of N-Arylacrylamides with Amino Acid Derivatives

Kyalo Stephen Kanyiva*, Sohei Makino, Takanori Shibata

*この研究の対応する著者

研究成果: Article査読

6 被引用数 (Scopus)

抄録

α-Aminoalkylation of N-arylacrylamides with amino acid derivatives was achieved by silver-catalysis in moderate to high yields. The reaction provides an efficient strategy for the synthesis of functionalized oxindoles, and is suitable for a wide range of N-arylacrylamides and amino acids, both of which are inexpensive and readily available. The oxindoles obtained were readily transformed into densely functionalized pyrroloindolines by deprotection and cyclization in one pot.

本文言語English
ページ(範囲)496-499
ページ数4
ジャーナルChemistry - An Asian Journal
13
5
DOI
出版ステータスPublished - 2018 3月 2

ASJC Scopus subject areas

  • 生化学
  • 有機化学

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