Similar metabolic responses to calorie restriction in lean and obese Zucker rats

Takuya Chiba*, Toshimitsu Komatsu, Masahiko Nakayama, Toshiyuki Adachi, Yukari Tamashiro, Hiroko Hayashi, Haruyoshi Yamaza, Yoshikazu Higami, Isao Shimokawa


研究成果: Article査読

25 被引用数 (Scopus)


Calorie restriction (CR), which is thought to be largely dependent on the neuroendocrine system modulated by insulin/insulin-like growth factor-I (IGF-I) and leptin signaling, decreases morbidity and increases lifespan in many organisms. To elucidate whether insulin and leptin sensitivities are indispensable in the metabolic adaptation to CR, we investigated the effects of CR on obese Zucker (fa/fa) rats and lean control (+/+) rats. CR did not fully improve insulin resistance in (fa/fa) rats. Nonetheless, CR induced neuropeptide Y (NPY) expression in the hypothalamic arcuate nucleus and metabolism related gene expression changes in the liver in (fa/fa) rats and (+/+) rats. Up-regulation of NPY augmented plasma corticosterone levels and suppressed pituitary growth hormone (GH) expression, thereby modulating adipocytokine production to induce tissue-specific insulin sensitivity. Thus, central NPY activation via peripheral signaling might play a crucial role in the effects of CR, even in insulin resistant and leptin receptor deficient conditions.

ジャーナルMolecular and Cellular Endocrinology
出版ステータスPublished - 2009 10月 15

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 内分泌学


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