Simultaneous comparison of thrombogenic reactions to different combinations of anticoagulants, activated clotting times, and materials

Mirei Nagai, Kiyotaka Iwasaki*, Mitsuo Umezu, Makoto Ozaki

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Thrombogenic reactions under multiple interactions of pharmacological agents, doses, and materials have not been well understood yet. The aim of this study was to investigate the ability to simultaneously compare thrombogenic reactions to different combinations of anticoagulants, doses, and blood-contacting materials, in a single human blood using an in vitro test method. Four venous blood samples were drawn from each of six healthy volunteers into syringes that contained two different amounts of heparin and argatroban to set the activated clotting time (ACT) to approximately 200 or 500 s, respectively. The four blood samples from each volunteer were immediately poured into two clinical-grade extracorporeal circulation tubes: a polyvinyl chloride (PVC) tube and a poly(2-methoxyethyl acrylate)-coated (PMEA) PVC tube. These tubes with an inner diameter of 12.7 mm were rotated at 183 rpm in a 37

本文言語English
ページ(範囲)1605-1612
ページ数8
ジャーナルJournal of Biomedical Materials Research - Part B Applied Biomaterials
102
8
DOI
出版ステータスPublished - 2014 11 1

ASJC Scopus subject areas

  • 生体材料
  • 生体医工学

フィンガープリント

「Simultaneous comparison of thrombogenic reactions to different combinations of anticoagulants, activated clotting times, and materials」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル