Single walled carbon nanotubes based regulation of proliferation and differentiation of mouse embryonic stem cells

Daxiang Cui*, Z. Wang, H. Zhang, J. Ruan, C. C. Bao, H. Yang, Asahi Toru, H. Song, K. Wang

*この研究の対応する著者

研究成果

1 被引用数 (Scopus)

抄録

Carbon nanotubes'bio-effects have become a hotspot. In recent years, my group and collaborators try to use single walled carbon nanotubes(SWCNTs) as drug delivery system to regulate proliferation and differentiation of mouse stem cells. We observed that low dose of SWCNTs stimulate stem cells'proliferation and differentiation, higher dose of SWCNTs improve stem cells' apoptosis. Y-27632, a selective inhibitor of p160 Rho-associated coiled-coil kinase, can conjugate with SWCNTs and form the nanocomposites, which markedly inhibit the apoptosis of mouse stem cells, improve the proliferation and differentiation of stem cells. The potential mechanism of effects of Y-27632-SWCNT composites on stem cells is also dicussed. Our primary results suggest that special enzyme modified SWCNTs can be used to regulate proliferation and differentiation of stem cells, which has potential application in stem cells-based therapy.

本文言語English
ホスト出版物のタイトルFullerenes, Nanotubes, and Carbon Nanostructures - 215th ECS Meeting
出版社Electrochemical Society Inc.
ページ63-67
ページ数5
13
ISBN(電子版)9781566777551
ISBN(印刷版)9781607681052
DOI
出版ステータスPublished - 2009

出版物シリーズ

名前ECS Transactions
番号13
19
ISSN(印刷版)1938-5862
ISSN(電子版)1938-6737

ASJC Scopus subject areas

  • 工学(全般)

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