抄録
The objective of this study is to investigate the effect of organic solvents on pseudopolymorph transformation kinetics for clarifying the transformation phenomenon. In our previous study, we observed anhydrate and dihydrate crystals of myo-inositol in water and/or an ethanol-water system and transformation phenomena. However, we could not determine the detailed transformation mechanism in organic solvents. Therefore, we attempted adding seed crystals to different alcohol solvents, which resulted in the transformation of seed crystals of a dihydrate into anhydrate crystals. The transformation kinetics increased with a decrease in the alkyl carbon number in the solvents and also with an increase in the ethanol mass fraction. During the transformation process, fine anhydrate crystals were observed on the surface of dihydrate crystals, and the dihydrate crystals were found to dissolve and gradually decrease in size. On the basis of these results, we propose that the hydrophilic nature of organic solvents is a significant factor determining the pseudopolymorph transformation kinetics of myo-inositol. The transformation phenomena proceeded easily upon the addition of dehydrate seed crystals, as if the solvent had the driving force for the crystallization of a stable polymorph. We classified this unique mechanism as a ''solvent-induced transformation.''
| 元の言語 | English |
|---|---|
| ページ（範囲） | 187-190 |
| ページ数 | 4 |
| ジャーナル | Journal of Chemical Engineering of Japan |
| 巻 | 44 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | Published - 2011 |
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ASJC Scopus subject areas
- Chemical Engineering(all)
- Chemistry(all)
これを引用
Solvent-induced transformation of myo-inositol crystal. / Kumashiro, Mizuki; Saitoh, Shunki; Kobayakawa, Azusa; Hirasawa, Izumi.
：: Journal of Chemical Engineering of Japan, 巻 44, 番号 3, 2011, p. 187-190.研究成果: Article
}
TY - JOUR
T1 - Solvent-induced transformation of myo-inositol crystal
AU - Kumashiro, Mizuki
AU - Saitoh, Shunki
AU - Kobayakawa, Azusa
AU - Hirasawa, Izumi
PY - 2011
Y1 - 2011
N2 - The objective of this study is to investigate the effect of organic solvents on pseudopolymorph transformation kinetics for clarifying the transformation phenomenon. In our previous study, we observed anhydrate and dihydrate crystals of myo-inositol in water and/or an ethanol-water system and transformation phenomena. However, we could not determine the detailed transformation mechanism in organic solvents. Therefore, we attempted adding seed crystals to different alcohol solvents, which resulted in the transformation of seed crystals of a dihydrate into anhydrate crystals. The transformation kinetics increased with a decrease in the alkyl carbon number in the solvents and also with an increase in the ethanol mass fraction. During the transformation process, fine anhydrate crystals were observed on the surface of dihydrate crystals, and the dihydrate crystals were found to dissolve and gradually decrease in size. On the basis of these results, we propose that the hydrophilic nature of organic solvents is a significant factor determining the pseudopolymorph transformation kinetics of myo-inositol. The transformation phenomena proceeded easily upon the addition of dehydrate seed crystals, as if the solvent had the driving force for the crystallization of a stable polymorph. We classified this unique mechanism as a ''solvent-induced transformation.''
AB - The objective of this study is to investigate the effect of organic solvents on pseudopolymorph transformation kinetics for clarifying the transformation phenomenon. In our previous study, we observed anhydrate and dihydrate crystals of myo-inositol in water and/or an ethanol-water system and transformation phenomena. However, we could not determine the detailed transformation mechanism in organic solvents. Therefore, we attempted adding seed crystals to different alcohol solvents, which resulted in the transformation of seed crystals of a dihydrate into anhydrate crystals. The transformation kinetics increased with a decrease in the alkyl carbon number in the solvents and also with an increase in the ethanol mass fraction. During the transformation process, fine anhydrate crystals were observed on the surface of dihydrate crystals, and the dihydrate crystals were found to dissolve and gradually decrease in size. On the basis of these results, we propose that the hydrophilic nature of organic solvents is a significant factor determining the pseudopolymorph transformation kinetics of myo-inositol. The transformation phenomena proceeded easily upon the addition of dehydrate seed crystals, as if the solvent had the driving force for the crystallization of a stable polymorph. We classified this unique mechanism as a ''solvent-induced transformation.''
KW - Pseudopolymorph Crystals
KW - Seeding Crystallization
KW - Transformation Kinetics
UR - http://www.scopus.com/inward/record.url?scp=79953043602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953043602&partnerID=8YFLogxK
U2 - 10.1252/jcej.10we233
DO - 10.1252/jcej.10we233
M3 - Article
AN - SCOPUS:79953043602
VL - 44
SP - 187
EP - 190
JO - Journal of Chemical Engineering of Japan
JF - Journal of Chemical Engineering of Japan
SN - 0021-9592
IS - 3
ER -