Some plasma component is essential for IL-6 secretion by neutrophils

Katsutaka Oishi, Kazuhiko Machida

研究成果: Article

7 引用 (Scopus)

抄録

Recently, the neutrophil has been shown to have the capacity to produce a number of cytokines. Among these cytokines, interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α) and IL-6 are typical examples of multifunctional cytokines involved in regulation of the immune response and inflammation. However, there are conflicting reports in the literature concerning the issue of whether IL-6 expression can be modulated in human neutrophils. In this study, we showed the spontaneous secretion of IL-1β, TNF-α and IL-6 by neutrophils. IL-6 secretion of neutrophils was effectively induced by IL- 1β. However, spontaneous or IL-1β induced secretion of IL-6 was observed only when the cells were cultured in autologous plasma. Then we examined the spontaneous secretion of cytokines by co-cultured leukocytes (neutrophils, monocytes, and lymphocytes). Surprisingly, IL-6 was dramatically secreted by the leukocytes only when the cells were cultured in autologous plasma, although IL-1β and TNF- α were secreted by the cells either in RPMI 1640 or in plasma. These observations suggest that the regulation of IL-6 production is qualitatively different from the production of IL-1β or TNF- α by leukocytes.

元の言語English
ページ(範囲)89-92
ページ数4
ジャーナルEnvironmental Health and Preventive Medicine
2
発行部数2
出版物ステータスPublished - 1997 7

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Interleukin-1
Interleukin-6
Neutrophils
Plasmas
Tumor Necrosis Factor-alpha
Cytokines
Leukocytes
Lymphocytes
Cultured Cells
Monocytes
Inflammation

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health

これを引用

Some plasma component is essential for IL-6 secretion by neutrophils. / Oishi, Katsutaka; Machida, Kazuhiko.

:: Environmental Health and Preventive Medicine, 巻 2, 番号 2, 07.1997, p. 89-92.

研究成果: Article

Oishi, Katsutaka ; Machida, Kazuhiko. / Some plasma component is essential for IL-6 secretion by neutrophils. :: Environmental Health and Preventive Medicine. 1997 ; 巻 2, 番号 2. pp. 89-92.
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