抄録
In proton therapy, the delivered dose should be monitored to a high degree of accuracy to avoid unnecessary exposure to healthy tissues and critical organs. Although positron emission tomography (PET) is most frequently used to verify the proton range, the nuclear reactions between protons and nuclei that generate positrons do not necessarily correspond to the actual proton range. Moreover, such imaging must be conducted after the treatment irradiation, because a PET gantry cannot be used in conjunction with a proton therapy beam. In this paper, we studied one-dimensional (1D) and two-dimensional (2D) distributions of prompt gamma rays of various energies, to determine the most suitable energy window for online monitoring in proton therapy. After an initial simulation study using the particle and heavy ion transport code system (PHITS), we irradiated a poly(methyl methacrylate) (PMMA) phantom with a 70-MeV proton beam to mimic proton range verification in a clinical situation. Using a newly developed Compton camera, we have experimentally confirmed for the first time that 4.4-MeV gamma rays emitted from 12C and 16O match the exact position of the Bragg peak in proton range verification.
| 元の言語 | English |
|---|---|
| ジャーナル | Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment |
| DOI | |
| 出版物ステータス | Accepted/In press - 2017 1 1 |
Fingerprint
ASJC Scopus subject areas
- Nuclear and High Energy Physics
- Instrumentation
これを引用
Spatially resolved measurement of wideband prompt gamma-ray emission toward on-line monitor for the future proton therapy. / Koide, A.; Kataoka, Jun; Taya, T.; Iwamoto, Y.; Sueoka, K.; Mochizuki, S.; Arimoto, M.; Inaniwa, T.
：: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 01.01.2017.研究成果: Article
}
TY - JOUR
T1 - Spatially resolved measurement of wideband prompt gamma-ray emission toward on-line monitor for the future proton therapy
AU - Koide, A.
AU - Kataoka, Jun
AU - Taya, T.
AU - Iwamoto, Y.
AU - Sueoka, K.
AU - Mochizuki, S.
AU - Arimoto, M.
AU - Inaniwa, T.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - In proton therapy, the delivered dose should be monitored to a high degree of accuracy to avoid unnecessary exposure to healthy tissues and critical organs. Although positron emission tomography (PET) is most frequently used to verify the proton range, the nuclear reactions between protons and nuclei that generate positrons do not necessarily correspond to the actual proton range. Moreover, such imaging must be conducted after the treatment irradiation, because a PET gantry cannot be used in conjunction with a proton therapy beam. In this paper, we studied one-dimensional (1D) and two-dimensional (2D) distributions of prompt gamma rays of various energies, to determine the most suitable energy window for online monitoring in proton therapy. After an initial simulation study using the particle and heavy ion transport code system (PHITS), we irradiated a poly(methyl methacrylate) (PMMA) phantom with a 70-MeV proton beam to mimic proton range verification in a clinical situation. Using a newly developed Compton camera, we have experimentally confirmed for the first time that 4.4-MeV gamma rays emitted from 12C and 16O match the exact position of the Bragg peak in proton range verification.
AB - In proton therapy, the delivered dose should be monitored to a high degree of accuracy to avoid unnecessary exposure to healthy tissues and critical organs. Although positron emission tomography (PET) is most frequently used to verify the proton range, the nuclear reactions between protons and nuclei that generate positrons do not necessarily correspond to the actual proton range. Moreover, such imaging must be conducted after the treatment irradiation, because a PET gantry cannot be used in conjunction with a proton therapy beam. In this paper, we studied one-dimensional (1D) and two-dimensional (2D) distributions of prompt gamma rays of various energies, to determine the most suitable energy window for online monitoring in proton therapy. After an initial simulation study using the particle and heavy ion transport code system (PHITS), we irradiated a poly(methyl methacrylate) (PMMA) phantom with a 70-MeV proton beam to mimic proton range verification in a clinical situation. Using a newly developed Compton camera, we have experimentally confirmed for the first time that 4.4-MeV gamma rays emitted from 12C and 16O match the exact position of the Bragg peak in proton range verification.
KW - Compton camera
KW - Particle therapy
KW - Prompt gamma rays
UR - http://www.scopus.com/inward/record.url?scp=85035025572&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85035025572&partnerID=8YFLogxK
U2 - 10.1016/j.nima.2017.10.020
DO - 10.1016/j.nima.2017.10.020
M3 - Article
AN - SCOPUS:85035025572
JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
SN - 0168-9002
ER -