Specific RNA protease inhibitors from in vitro selection.

S. Yamamoto, S. Saito, T. Tanaka, Yo Kikuchi

研究成果: Article査読

抄録

RNA aptamers that bind to and inhibit the proteolytic activity of subtilisin BPN' are selected in vitro from pools of random RNA. The RNAs in vitro transcribed from the isolated clones show highly specific inhibition toward the microbial serine proteases. From the sequences of the isolated clones, a C/A-rich sequence was obtained. The kinetic features of the common C/A-rich sequence will be discussed.

本文言語English
ページ(範囲)215-216
ページ数2
ジャーナルNucleic acids symposium series
42
出版ステータスPublished - 1999
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