Src-homology domain 2 is responsible for transcriptional suppression induced by expression of Lck

M. Ohta, H. Nagai, H. Nyunoya*, K. Shimotohno

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Overexpression of Lck was shown, by our previous study, to suppress gene transcription from various viral and cellular promoters. The suppression of transcription from human T-cell leukemia virus promoter by Lck was independent of the presence of the enhancer core sequences within the long terminal repeat. The suppression of transcription was observed with Lck mutants that had either diminished or enhanced tyrosine-kinase activity. A mutant lacking the myristylation site also suppressed transcription. From the analysis with various deletion mutants of Lck, it was suggested that Src-homology domain 2 (SH2) is both necessary and sufficient for the suppression of transcription. A similar effect was also observed with the SH2 domain of the v-src gene. Thus, overexpression of Lck could suppress gene expression through a unique function of the SH2 domain.

本文言語English
ページ(範囲)989-997
ページ数9
ジャーナルOncogene
12
5
出版ステータスPublished - 1996 4 17
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 遺伝学
  • 癌研究

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