Stereocontrolled preparation of 1,2-diol with quaternary chiral center

Yoshihisa Murata, Tomoyuki Kamino, Seijiro Hosokawa, Susumu Kobayashi

研究成果: Article

30 引用 (Scopus)

抜粋

Development of an enantio- and stereoselective construction of 1,2-diols including a quaternary chiral center was achieved by a titanium-mediated aldol reaction of lactates bearing chiral oxazolidine-2-ones. anti-Aldol and syn-aldol were selectively obtained by the choice of a benzyl and TBS protecting group, respectively. Plausible transition states are also shown based on the stereochemistry of the enolate anion.

元の言語English
ページ(範囲)8121-8123
ページ数3
ジャーナルTetrahedron Letters
43
発行部数45
DOI
出版物ステータスPublished - 2002 11 4
外部発表Yes

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ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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