Stereoselective construction of a quaternary carbon substituted with multifunctional groups: Application to the concise synthesis of (+)-ethosuximide

Tomoaki Abe, Tatsuo Suzuki, Kazuhiko Sekiguchi, Seijiro Hosokawa, Susumu Kobayashi*

*この研究の対応する著者

研究成果査読

35 被引用数 (Scopus)

抄録

Synthetically useful β,γ-unsaturated carbonyl compounds having a quaternary carbon at the α-position were prepared with high stereoselectivity by the reaction of a dienolate anion derived from α,β-unsaturated imide having a chiral auxiliary and electrophiles (ethyl acetate and allyl iodide as the C2 and C3 unit, respectively). This method was applied to a short asymmetric synthesis of (+)-ethosuximide.

本文言語English
ページ(範囲)9303-9305
ページ数3
ジャーナルTetrahedron Letters
44
52
DOI
出版ステータスPublished - 2003 12 22
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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