Stereoselective total synthesis of garsubellin A

Masahiro Uwamori, Masahisa Nakada*

*この研究の対応する著者

研究成果査読

20 被引用数 (Scopus)

抄録

The stereoselective total synthesis of garsubellin A is described. The total synthesis was achieved through the stereoselective construction of a bicyclo3.3.1nonane derivative via a three-step sequence: intramolecular cyclopropanation, formation of a germinal dimethyl group, and regioselective ring opening of cyclopropane. To complete the total synthesis of garsubellin A, chemo-And stereoselective hydrogenation to generate the C8 stereogenic center is followed by the formation of the fused tetrahydrofuran ring by a regioselective epoxide-opening reaction with C3 ketone, and finally cross metathesis to construct two prenyl groups.

本文言語English
ページ(範囲)141-145
ページ数5
ジャーナルJournal of Antibiotics
66
3
DOI
出版ステータスPublished - 2013 3

ASJC Scopus subject areas

  • 薬理学
  • 創薬

フィンガープリント

「Stereoselective total synthesis of garsubellin A」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル