抜粋
Total synthesis of (±)-hyperforin is described. This total synthesis features an approach via a bicyclo[ 3.3.1]nonane derivative prepared by a three-step sequence: intramolecular cyclopropanation, construction of the C8 all-carbon quaternary stereogenic center, and subsequent regioselective ring opening of cyclopropane. Further steps to obtain (±)-hyperforin include chemo- and stereoselective hydrogenation to generate the C7 stereogenic center, formation of the C9 isopropyl ketone using an organocerium reagent, and cross-metathesis at high temperatures to construct trisubstituted alkenes in side-chains.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 2022-2025 |
| ページ数 | 4 |
| ジャーナル | Tetrahedron Letters |
| 巻 | 54 |
| 発行部数 | 15 |
| DOI | |
| 出版物ステータス | Published - 2013 4 10 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
フィンガープリント Stereoselective total synthesis of (±)-hyperforin via intramolecular cyclopropanation' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Uwamori, M., & Nakada, M. (2013). Stereoselective total synthesis of (±)-hyperforin via intramolecular cyclopropanation. Tetrahedron Letters, 54(15), 2022-2025. https://doi.org/10.1016/j.tetlet.2013.02.021