抄録
Total synthesis of (±)-hyperforin is described. This total synthesis features an approach via a bicyclo[ 3.3.1]nonane derivative prepared by a three-step sequence: intramolecular cyclopropanation, construction of the C8 all-carbon quaternary stereogenic center, and subsequent regioselective ring opening of cyclopropane. Further steps to obtain (±)-hyperforin include chemo- and stereoselective hydrogenation to generate the C7 stereogenic center, formation of the C9 isopropyl ketone using an organocerium reagent, and cross-metathesis at high temperatures to construct trisubstituted alkenes in side-chains.
本文言語 | English |
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ページ(範囲) | 2022-2025 |
ページ数 | 4 |
ジャーナル | Tetrahedron Letters |
巻 | 54 |
号 | 15 |
DOI | |
出版ステータス | Published - 2013 4月 10 |
ASJC Scopus subject areas
- 生化学
- 創薬
- 有機化学