A chiral pyrimidyl alkanol with high enantiomeric excess is transformed into L-valine with high e.e. by a notable oxidative cleavage of pyrimidine ring using ruthenium oxide as a key step. This process would correlate natural α-amino acids with a chiral pyrimidyl alkanol, which is reported to possess an asymmetric autocatalytic activity with amplification of e.e.
|出版ステータス||Published - 1998 11 24|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Organic Chemistry