Stimulation by proopiomelanocortin-derived peptides of LH release by bullfrog dispersed anterior pituitary cells

Tomomi Aida, Atsuko Oguchi, Shawichi Iwamuro, Kazutoshi Yamamoto, Sakae Kikuyama

    研究成果: Article

    4 引用 (Scopus)

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    Labeling and immunoprecipitation experiments confirmed that three proopiomelanocortin (POMC)-derived peptides, the N-terminal peptide of POMC (NPP), joining peptide (JP) and adrenocorticotropic hormone (ACTH), were released by the bullfrog (Rana catesbeiana) anterior pituitary. The effects of these three peptides on luteinizing hormone (LH) release by bullfrog dispersed anterior pituitary cells were studied. NPP and ACTH, but not JP, enhanced LH release concentration-dependently. Approximately 6 hr elapsed before the gonadotrophs responded to NPP and ACTH by releasing LH, whereas their response to human GnRH (hGnRH) was faster, suggesting that the modes of action of these two peptides and hGnRH differ. These results raise the possibility that NPP and ACTH act as paracrine factors in the bullfrog pituitary to enhance LH release either directly or indirectly.

    元の言語English
    ページ(範囲)827-831
    ページ数5
    ジャーナルZoological Science
    14
    発行部数5
    出版物ステータスPublished - 1997 10

    ASJC Scopus subject areas

    • Animal Science and Zoology

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    Aida, T., Oguchi, A., Iwamuro, S., Yamamoto, K., & Kikuyama, S. (1997). Stimulation by proopiomelanocortin-derived peptides of LH release by bullfrog dispersed anterior pituitary cells. Zoological Science, 14(5), 827-831.