Stimulation by proopiomelanocortin-derived peptides of LH release by bullfrog dispersed anterior pituitary cells

Tomomi Aida, Atsuko Oguchi, Shawichi Iwamuro, Kazutoshi Yamamoto, Sakae Kikuyama

    研究成果: Article

    4 引用 (Scopus)

    抄録

    Labeling and immunoprecipitation experiments confirmed that three proopiomelanocortin (POMC)-derived peptides, the N-terminal peptide of POMC (NPP), joining peptide (JP) and adrenocorticotropic hormone (ACTH), were released by the bullfrog (Rana catesbeiana) anterior pituitary. The effects of these three peptides on luteinizing hormone (LH) release by bullfrog dispersed anterior pituitary cells were studied. NPP and ACTH, but not JP, enhanced LH release concentration-dependently. Approximately 6 hr elapsed before the gonadotrophs responded to NPP and ACTH by releasing LH, whereas their response to human GnRH (hGnRH) was faster, suggesting that the modes of action of these two peptides and hGnRH differ. These results raise the possibility that NPP and ACTH act as paracrine factors in the bullfrog pituitary to enhance LH release either directly or indirectly.

    元の言語English
    ページ(範囲)827-831
    ページ数5
    ジャーナルZoological Science
    14
    発行部数5
    出版物ステータスPublished - 1997 10

    Fingerprint

    pro-opiomelanocortin
    peptide hormones
    anterior pituitary
    luteinizing hormone
    corticotropin
    peptides
    cells
    Lithobates catesbeianus
    mechanism of action

    ASJC Scopus subject areas

    • Animal Science and Zoology

    これを引用

    Aida, T., Oguchi, A., Iwamuro, S., Yamamoto, K., & Kikuyama, S. (1997). Stimulation by proopiomelanocortin-derived peptides of LH release by bullfrog dispersed anterior pituitary cells. Zoological Science, 14(5), 827-831.

    Stimulation by proopiomelanocortin-derived peptides of LH release by bullfrog dispersed anterior pituitary cells. / Aida, Tomomi; Oguchi, Atsuko; Iwamuro, Shawichi; Yamamoto, Kazutoshi; Kikuyama, Sakae.

    :: Zoological Science, 巻 14, 番号 5, 10.1997, p. 827-831.

    研究成果: Article

    Aida, T, Oguchi, A, Iwamuro, S, Yamamoto, K & Kikuyama, S 1997, 'Stimulation by proopiomelanocortin-derived peptides of LH release by bullfrog dispersed anterior pituitary cells', Zoological Science, 巻. 14, 番号 5, pp. 827-831.
    Aida, Tomomi ; Oguchi, Atsuko ; Iwamuro, Shawichi ; Yamamoto, Kazutoshi ; Kikuyama, Sakae. / Stimulation by proopiomelanocortin-derived peptides of LH release by bullfrog dispersed anterior pituitary cells. :: Zoological Science. 1997 ; 巻 14, 番号 5. pp. 827-831.
    @article{040a3ba09655477cacffbf5b44b698fe,
    title = "Stimulation by proopiomelanocortin-derived peptides of LH release by bullfrog dispersed anterior pituitary cells",
    abstract = "Labeling and immunoprecipitation experiments confirmed that three proopiomelanocortin (POMC)-derived peptides, the N-terminal peptide of POMC (NPP), joining peptide (JP) and adrenocorticotropic hormone (ACTH), were released by the bullfrog (Rana catesbeiana) anterior pituitary. The effects of these three peptides on luteinizing hormone (LH) release by bullfrog dispersed anterior pituitary cells were studied. NPP and ACTH, but not JP, enhanced LH release concentration-dependently. Approximately 6 hr elapsed before the gonadotrophs responded to NPP and ACTH by releasing LH, whereas their response to human GnRH (hGnRH) was faster, suggesting that the modes of action of these two peptides and hGnRH differ. These results raise the possibility that NPP and ACTH act as paracrine factors in the bullfrog pituitary to enhance LH release either directly or indirectly.",
    author = "Tomomi Aida and Atsuko Oguchi and Shawichi Iwamuro and Kazutoshi Yamamoto and Sakae Kikuyama",
    year = "1997",
    month = "10",
    language = "English",
    volume = "14",
    pages = "827--831",
    journal = "Zoological Science",
    issn = "0289-0003",
    publisher = "Zoological Society of Japan",
    number = "5",

    }

    TY - JOUR

    T1 - Stimulation by proopiomelanocortin-derived peptides of LH release by bullfrog dispersed anterior pituitary cells

    AU - Aida, Tomomi

    AU - Oguchi, Atsuko

    AU - Iwamuro, Shawichi

    AU - Yamamoto, Kazutoshi

    AU - Kikuyama, Sakae

    PY - 1997/10

    Y1 - 1997/10

    N2 - Labeling and immunoprecipitation experiments confirmed that three proopiomelanocortin (POMC)-derived peptides, the N-terminal peptide of POMC (NPP), joining peptide (JP) and adrenocorticotropic hormone (ACTH), were released by the bullfrog (Rana catesbeiana) anterior pituitary. The effects of these three peptides on luteinizing hormone (LH) release by bullfrog dispersed anterior pituitary cells were studied. NPP and ACTH, but not JP, enhanced LH release concentration-dependently. Approximately 6 hr elapsed before the gonadotrophs responded to NPP and ACTH by releasing LH, whereas their response to human GnRH (hGnRH) was faster, suggesting that the modes of action of these two peptides and hGnRH differ. These results raise the possibility that NPP and ACTH act as paracrine factors in the bullfrog pituitary to enhance LH release either directly or indirectly.

    AB - Labeling and immunoprecipitation experiments confirmed that three proopiomelanocortin (POMC)-derived peptides, the N-terminal peptide of POMC (NPP), joining peptide (JP) and adrenocorticotropic hormone (ACTH), were released by the bullfrog (Rana catesbeiana) anterior pituitary. The effects of these three peptides on luteinizing hormone (LH) release by bullfrog dispersed anterior pituitary cells were studied. NPP and ACTH, but not JP, enhanced LH release concentration-dependently. Approximately 6 hr elapsed before the gonadotrophs responded to NPP and ACTH by releasing LH, whereas their response to human GnRH (hGnRH) was faster, suggesting that the modes of action of these two peptides and hGnRH differ. These results raise the possibility that NPP and ACTH act as paracrine factors in the bullfrog pituitary to enhance LH release either directly or indirectly.

    UR - http://www.scopus.com/inward/record.url?scp=0031243645&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0031243645&partnerID=8YFLogxK

    M3 - Article

    C2 - 9450395

    AN - SCOPUS:0031243645

    VL - 14

    SP - 827

    EP - 831

    JO - Zoological Science

    JF - Zoological Science

    SN - 0289-0003

    IS - 5

    ER -