Stimulation of nerve growth factor synthesis and secretion by fellutamide A in vitro.

K. Yamaguchi, T. Tsuji, S. Wakuri, Kazunaga Yazawa, K. Kondo, H. Shigemori, J. Kobayashi

研究成果: Article査読

40 被引用数 (Scopus)

抄録

Fellutamide A, a tripeptide derivative from Penicillium fellutanum was found to be a potent enhancer of nerve growth factor (NGF) synthesis and secretion in vitro. This compound enhanced production of NGF in L-M cells, rat brain cells, and rat glial cells. The mode of action of this compound was suggested to be different from that of a known NGF inducer, epinephrine, as inducing activities of fellutamide A and epinephrine were additive when they were admixed at the concentration which gave saturation in its respective activity. Furthermore, fellutamide A but not epinephrine induced production of NGF in the rat brain cells. NGF-inducing activity of several tripeptides and other compounds related to fellutamide A was examined.

本文言語English
ページ(範囲)195-199
ページ数5
ジャーナルBioscience, Biotechnology, and Biochemistry
57
2
出版ステータスPublished - 1993 2
外部発表はい

ASJC Scopus subject areas

  • 食品科学
  • 生化学、遺伝学、分子生物学(全般)
  • 生化学
  • バイオテクノロジー
  • 化学(その他)
  • 応用微生物学とバイオテクノロジー

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