Stimulation of Spermatid Phosphofructokinase by Fructose 2,6‐Bisphosphate from Rat Testes: fructose 2, 6‐bisphosphate/phosphofructokinase/spermatids/rats

MASAHISA NAKAMURA, AKIRA SUZUKI, SHOICHI OKINAGA, KIYOSHI ARAI

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Effect of fructose 2, 6‐bisphosphate on 6‐phosphofructokinase (ATP: D‐fructose‐6‐phosphate 1‐phosphotransferase, EC 2.7.1.11) in spermatid extract from rat testes was studied. Fructose 2, 6‐bisphosphate stimulated the enzyme greatly by increasing its affinity for fructose 6‐phosphate and relieving the inhibition by ATP. Fructose 2, 6‐bisphosphate (0.8 μM) was required for 50% activation of 6‐phosphofructokinase (PFK). In addition, fructose 2, 6‐bisphosphate, AMP and fructose 6‐phosphate acted cooperatively to stimulate the activity of PFK. This stimulation may play an important role in the regulation of glycolysis in spermatids of rat testes.

本文言語English
ページ(範囲)11-16
ページ数6
ジャーナルDevelopment Growth and Differentiation
26
1
DOI
出版ステータスPublished - 1984
外部発表はい

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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