Stressful delivery influences circulating thrombopoietin (TPO) levels in newborns: Possible role for cortisol in TPO-mpl binding

Kazuhide Ikeno, Kenichi Koike*, Akihiro Takeshita, Kaori Shinjo, Tsukasa Higuchi, Tetsuo Nakabayashi, Sachiko Akanuma, Kiyoko Hizume, Akira Ishiguro, Kinya Ogami, Takashi Kato, Hiroshi Miyazaki, Ryuzo Ohno, Atsushi Komiyama

*この研究の対応する著者

研究成果: Article査読

16 被引用数 (Scopus)

抄録

The regulation mechanism of circulating thrombopoietin (TPO) level in human newborns remains unknown. In the present study, we examined whether the TPO concentrations in cord blood were influenced by the difference in the delivery method and the presence or absence of maternal/fetal complications. Cortisol levels were simultaneously measured to assess the adrenal response of fetuses. Both the TPO level and the cortisol level were substantially greater in the neonates delivered vaginally with and without the complications than in those delivered by cesarean section without the complications. The binding assay showed that the incubation of mpl+/BaF3 cells with cortisol gave rise to a significant decrease in the binding sites of TPO. These results suggest that the stress to the fetuses near the time of delivery affects the cord blood TPO levels, which may be mediated in part by the action of cortisol on the TPO-mpl binding system. Copyright (C) 2000 Elsevier Science Ireland Ltd.

本文言語English
ページ(範囲)225-235
ページ数11
ジャーナルEarly Human Development
58
3
DOI
出版ステータスPublished - 2000 6
外部発表はい

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 産婦人科学

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