Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

Youcef Bouchekioua, Iku Tsutsui-Kimura, Hiromi Sano, Miwako Koizumi, Kenji F. Tanaka, Keitaro Yoshida, Yutaka Kosaki, Shigeru Watanabe, Masaru Mimura

研究成果: Article

2 引用 (Scopus)

抄録

Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.

元の言語English
ジャーナルNeuroscience Research
DOI
出版物ステータスAccepted/In press - 2017

Fingerprint

Optogenetics
Dopamine D1 Receptors
Substantia Nigra
Rodentia
Pharmacology
Pars Reticulata

ASJC Scopus subject areas

  • Neuroscience(all)

これを引用

Bouchekioua, Y., Tsutsui-Kimura, I., Sano, H., Koizumi, M., Tanaka, K. F., Yoshida, K., ... Mimura, M. (受理済み/印刷中). Striatonigral direct pathway activation is sufficient to induce repetitive behaviors. Neuroscience Research. https://doi.org/10.1016/j.neures.2017.09.007

Striatonigral direct pathway activation is sufficient to induce repetitive behaviors. / Bouchekioua, Youcef; Tsutsui-Kimura, Iku; Sano, Hiromi; Koizumi, Miwako; Tanaka, Kenji F.; Yoshida, Keitaro; Kosaki, Yutaka; Watanabe, Shigeru; Mimura, Masaru.

:: Neuroscience Research, 2017.

研究成果: Article

Bouchekioua, Y, Tsutsui-Kimura, I, Sano, H, Koizumi, M, Tanaka, KF, Yoshida, K, Kosaki, Y, Watanabe, S & Mimura, M 2017, 'Striatonigral direct pathway activation is sufficient to induce repetitive behaviors', Neuroscience Research. https://doi.org/10.1016/j.neures.2017.09.007
Bouchekioua, Youcef ; Tsutsui-Kimura, Iku ; Sano, Hiromi ; Koizumi, Miwako ; Tanaka, Kenji F. ; Yoshida, Keitaro ; Kosaki, Yutaka ; Watanabe, Shigeru ; Mimura, Masaru. / Striatonigral direct pathway activation is sufficient to induce repetitive behaviors. :: Neuroscience Research. 2017.
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AU - Tanaka, Kenji F.

AU - Yoshida, Keitaro

AU - Kosaki, Yutaka

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AU - Mimura, Masaru

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