Structural and biological assessment of zinc doped hydroxyapatite nanoparticles

Cristina Liana Popa, Aurélien Deniaud, Isabelle Michaud-Soret, Régis Guégan, Mikael Motelica-Heino, Daniela Predoi*

*この研究の対応する著者

研究成果: Article査読

36 被引用数 (Scopus)

抄録

The aim of the current research work was to study the physicochemical and biological properties of synthesized zinc doped hydroxyapatite (ZnHAp) nanoparticles with Zn concentrations xZn = 0 (HAp), xZn = 0.07 (7ZnHAp), and xZn = 0.1 (10ZnHAp) for potential use in biological applications. The morphology, size, compositions, and incorporation of zinc into hydroxyapatite were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR), Raman scattering, and X-Ray Photoelectron Spectroscopy (XPS). In addition, the cytotoxicity of ZnHAp nanoparticles was tested on both E. coli bacteria and human hepatocarcinoma cell line HepG2. The results showed that ZnHAp nanoparticles (HAp, 7ZnHAp, and 10ZnHAp) have slightly elongated morphologies with average diameters between 25 nm and 18 nm. On the other hand, a uniform and homogeneous distribution of the constituent elements (calcium, phosphorus, zinc, and oxygen) in the ZnHAp powder was noticed. Besides, FTIR and Raman analyses confirmed the proper hydroxyapatite structure of the synthesized ZnHAp nanoparticles with the signature of phosphate, carbonate, and hydroxyl groups. Moreover, it can be concluded that Zn doping at the tested concentrations is not inducing a specific prokaryote or eukaryote toxicity in HAp compounds.

本文言語English
論文番号1062878
ジャーナルJournal of Nanomaterials
2016
DOI
出版ステータスPublished - 2016
外部発表はい

ASJC Scopus subject areas

  • 材料科学(全般)

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