Structural and Functional Aspects of Placental Lactogens (PLs) and Ovarian 20-Hydroxysteroid Dehydrogenase (20ar-HSD) in the Rat

Kunio Shiota, Mitsuko Hirosawa, Naka Hattori, Saki Itonori, Ryuich Miura, Ken Noda, Michio Takahashi, Tomoya Ogawa

研究成果: Article

抜粋

The placenta plays an essential role in fetal growth and the maintenance of pregnancy. Successful development and maturation of the embryo is totally dependent on placental function. The main endocrine participation of the placenta is attributed to placental lactogens (PLs). Progesterone is essential for pregnancy in all mammals and is secreted by the ovary and placenta, depending on the animal species. In the rat, the main source of progesterone throughout pregnancy is the ovary, and 20a- hydroxysteroid dehydrogenase (20a-HSD) is a key enzyme for ovarian progesterone secretion. The primary action of prolactin (PRL) in the maintenance of ovarian progesterone secretion is suppression of the activity of ovarian 20a-HSD. In this review, the sequence homologies between cDNAs for PLs and PRL and the intimate functional relationship between the ovary and placenta are discussed. We postulate the possibility of co-evolution of PLs and ovarian 20a-HSD.

元の言語English
ジャーナルEndocrine Journal
41
DOI
出版物ステータスPublished - 1994
外部発表Yes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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