Structural optimization of cyclic peptides that efficiently detect denatured collagen

Koh K. Takita, Kazunori Fujii, Kento Ishii, Takaki Koide

研究成果: Article

3 引用 (Scopus)

抜粋

To develop a facile method for detecting denatured collagen, we investigated the structure-activity relationship of cyclic collagen-mimetic peptides (cCMPs). Reported cCMP prototypes tend to self-assemble and they must be disassembled just before use. Introducing charge repulsion and a deformation in the peptide backbone structure enabled cCMPs to detect denatured collagen without a pre-treatment for disassembly. Using the optimized cCMP, types I-V collagen were detected by western blotting and denatured collagen fibrils were visualized in a cell culture system.

元の言語English
ページ(範囲)7380-7387
ページ数8
ジャーナルOrganic and Biomolecular Chemistry
17
発行部数31
DOI
出版物ステータスPublished - 2019 1 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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