Structural optimization of cyclic peptides that efficiently detect denatured collagen

Koh K. Takita, Kazunori K. Fujii, Kento Ishii, Takaki Koide*

*この研究の対応する著者

研究成果: Article査読

4 被引用数 (Scopus)

抄録

To develop a facile method for detecting denatured collagen, we investigated the structure-activity relationship of cyclic collagen-mimetic peptides (cCMPs). Reported cCMP prototypes tend to self-assemble and they must be disassembled just before use. Introducing charge repulsion and a deformation in the peptide backbone structure enabled cCMPs to detect denatured collagen without a pre-treatment for disassembly. Using the optimized cCMP, types I-V collagen were detected by western blotting and denatured collagen fibrils were visualized in a cell culture system.

本文言語English
ページ(範囲)7380-7387
ページ数8
ジャーナルOrganic and Biomolecular Chemistry
17
31
DOI
出版ステータスPublished - 2019

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

フィンガープリント

「Structural optimization of cyclic peptides that efficiently detect denatured collagen」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル