Structure and sequence of the mouse V1a and V1b vasopressin receptor genes

Shintaro Kikuchi, Akito Tanoue, Nobuhito Goda, Nobutake Matsuo, Gozoh Tsujimoto

研究成果: Article査読

11 被引用数 (Scopus)

抄録

The structural organization and 5'-flanking region of the mouse V1a and V1b vasopressin receptor genes were determined. The mouse V1a receptor gene was located within an 8-kb XbaI fragment, and the mouse V1b receptor gene was located within a 14-kb EcoRV fragment. Both genes were comprised of two coding exons that were separated by a 2.3-kb and a 8.0-kb intron, respectively, located before the respective seventh transmembrane domain of the receptor sequence. The availability of these genes would allow us to study the functional role of V1a and V1b receptors by disrupting the gene in mice.

本文言語English
ページ(範囲)388-392
ページ数5
ジャーナルJapanese Journal of Pharmacology
81
4
DOI
出版ステータスPublished - 1999
外部発表はい

ASJC Scopus subject areas

  • Pharmacology

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