抄録
The enantioselective total synthesis of the potent HMGCoA reductase inhibitors FR901512 (1) and FR901516 (2) is reviewed. FR901512 was prepared in 15 steps from commercially available compound via 2 in 16.3% overall yield (89% average yield). This study validated the applicability and reliability of the catalytic asymmetric Nozaki-Hiyama reactions that were developed by us. These reactions enabled the concise, efficient, and protecting-group-free enantioselective total syntheses of these new statins.
本文言語 | English |
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ページ(範囲) | 3694-3707 |
ページ数 | 14 |
ジャーナル | Synthesis |
号 | 21 |
DOI | |
出版ステータス | Published - 2009 12月 21 |
ASJC Scopus subject areas
- 触媒
- 有機化学