Structure elucidation and enantioselective total synthesis of the potent HMG-CoA reductase inhibitor FR901512 via catalytic asymmetric Nozaki-Hiyama reactions

Masahiro Inoue, Masahisa Nakada*

*この研究の対応する著者

研究成果: Article査読

31 被引用数 (Scopus)

抄録

The structure elucidation and enantioselective total synthesis of the potent HMG-CoA reductase inhibitor FR901512 were accomplished. FR901512 was prepared in 15 steps from the commercially available 2-bromo-4-methylbenzaldehyde via FR901516 in 16.3% overall yield (89% average yield). The catalytic asymmetric Nozaki-Hiyama reactions developed by us proved their applicability and reliability through this work, enabling the concise, efficient, and protecting-group-free enantioselective total syntheses of these new statins.

本文言語English
ページ(範囲)4164-4165
ページ数2
ジャーナルJournal of the American Chemical Society
129
14
DOI
出版ステータスPublished - 2007 4 11

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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