Structure of cell networks critically determines oscillation regularity

Hiroshi Kori*, Yoji Kawamura, Naoki Masuda

*この研究の対応する著者

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Biological rhythms are generated by pacemaker organs, such as the heart pacemaker organ (the sinoatrial node) and the master clock of the circadian rhythms (the suprachiasmatic nucleus), which are composed of a network of autonomously oscillatory cells. Such biological rhythms have notable periodicity despite the internal and external noise present in each cell. Previous experimental studies indicate that the regularity of oscillatory dynamics is enhanced when noisy oscillators interact and become synchronized. This effect, called the collective enhancement of temporal precision, has been studied theoretically using particular assumptions. In this study, we propose a general theoretical framework that enables us to understand the dependence of temporal precision on network parameters including size, connectivity, and coupling intensity; this effect has been poorly understood to date. Our framework is based on a phase oscillator model that is applicable to general oscillator networks with any coupling mechanism if coupling and noise are sufficiently weak. In particular, we can manage general directed and weighted networks. We quantify the precision of the activity of a single cell and the mean activity of an arbitrary subset of cells. We find that, in general undirected networks, the standard deviation of cycle-to-cycle periods scales with the system size N as 1/N, but only up to a certain system size N * that depends on network parameters. Enhancement of temporal precision is ineffective when N>N *. We provide an example in which temporal precision considerably improves with increasing N while the level of synchrony remains almost constant; temporal precision and synchrony are independent dynamical properties. We also reveal the advantage of long-range interactions among cells to temporal precision.

本文言語English
ページ(範囲)61-72
ページ数12
ジャーナルJournal of Theoretical Biology
297
DOI
出版ステータスPublished - 2012 3 21
外部発表はい

ASJC Scopus subject areas

  • 統計学および確率
  • モデリングとシミュレーション
  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)
  • 農業および生物科学(全般)
  • 応用数学

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