Structure of the liposome composed of lipid-heme and phospholipids

Makoto Yuasa, Kazukiyo Aiba, Yoshitaka Ogata, Hiroyuki Nishide, Eishun Tsuchida*

*この研究の対応する著者

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The amphiphilic heme derivative, 5,10,15,20-tetra(α,α,α,α-o-(2′,2′-dimethyl-20′-(2′-trimethylammonioethyl) phosphonatoxyicosanamido)pheny)phorphinatoiron(II) (lipid-heme), formed a stable liposome (Φ ≈ 400 Å) with phospholipids. Differential scanning calorimetry showed that incorporation of the lipid-heme in the liposome bilayer (lipid/lipid-heme > 25) causes no disordering of the bilayer structure. Ligation of a bulky ligand to the lipid-heme liposome indicated that the lipid-heme situates facing predominantly outwards in the liposome. The closed vesicle structure and the stability of the lipid-heme liposome were also confirmed by the encapsulating capability of the fluorescence compound.

本文言語English
ページ(範囲)558-565
ページ数8
ジャーナルBBA - Biomembranes
860
3
DOI
出版ステータスPublished - 1986 9 11

ASJC Scopus subject areas

  • 生化学
  • 生物理学
  • 細胞生物学

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