Structures and diverse functions of frog growth hormone-releasing peptide (fGRP) and its related peptides (fGRP-RPs): A review

Kazuyoshi Ukena, Aya Koda, Kazutoshi Yamamoto, Eiko Iwakoshi-Ukena, Hiroyuki Minakata, Sakae Kikuyama, Kazuyoshi Tsutsui*

*この研究の対応する著者

研究成果: Article査読

4 被引用数 (Scopus)

抄録

A new Arg-Phe-NH2 (RFamide) peptide has been discovered in the amphibian hypothalamus. The cell bodies and terminals containing this peptide were localized in the suprachiasmatic nucleus and median eminence, respectively. This peptide was further revealed to have a considerable growth hormone (GH)-releasing activity in vitro and in vivo and hence designated as frog GH-releasing peptide (fGRP). Molecular cloning of cDNA encoding the fGRP precursor polypeptide revealed that it encodes fGRP and its putative gene-related peptides (fGRP-RP-1, -RP-2, and -RP-3). Subsequently, we identified these putative fGRP-RPs as mature peptides and analyzed their hypophysiotropic activities. Only fGRP-RP-2 stimulated the release of GH and prolactin (PRL) in vitro and in vivo. Thus, in addition to fGRP, fGRP-RP-2 acts as a hypothalamic factor on the frog pituitary to stimulate the release of GH and PRL.

本文言語English
ページ(範囲)815-821
ページ数7
ジャーナルJournal of Experimental Zoology Part A: Comparative Experimental Biology
305
9
DOI
出版ステータスPublished - 2006 9 1
外部発表はい

ASJC Scopus subject areas

  • 動物科学および動物学

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