Structures and Synthesis of Hitoyopodins: Bioactive Aromatic Sesquiterpenoids Produced by the Mushroom Coprinopsis cinerea

Junnosuke Otaka, Takeshi Shimizu, Yushi Futamura, Daisuke Hashizume, Hiroyuki Osada*

*この研究の対応する著者

研究成果: Article査読

13 被引用数 (Scopus)

抄録

The structures of sesquiterpenoids hitoyopodin A (1) and its hydroxy derivatives 2 and 3 from the mushroom Coprinopsis cinerea are reported. Their absolute structures (1-3) with a benzoxabicyclo[3.2.1]octane core were determined by spectroscopy, X-ray crystallography, and total synthesis of 1. Compound 1 displays antiproliferative activity against HL-60 cancer cells and the malarial parasite Plasmodium falciparum. It is proposed that 1 acts as a crucial precursor in the biosynthesis of 2, 3, and lagopodins.

本文言語English
ページ(範囲)6294-6297
ページ数4
ジャーナルOrganic Letters
20
19
DOI
出版ステータスPublished - 2018 10月 5
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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