The 'Raman spectroscopic signature of life' is a Raman band at 1602 cm-1 that sharply reflects the metabolic activity of cell mitochondria. Here we report the study of thissignature in isolated yeast mitochondria. The existence and behaviour of the 1602 cm-1 band in isolated mitochondria have been confirmed to be the same as in living yeast cells: the intensity of the band decreases with timewhen a respiration inhibitor, sodium azide, is added. The present study shows the significance of isolated mitochondria in elucidating the origin of this still unassigned Raman band.
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