Subacute effects of capsaicinoids on the distribution of white blood cells in rats

Shoko Aritoshi, Shogo Sato, Mari Kumazawa, Takamasa Ban, Jun Tanihata, Kaoru Tachiyashiki, Kazuhiko Imaizumi

    研究成果: Article

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    The subacute effects of dihydrocapsaincin (DHC) and capsaicin (CAP) (dose = 3mg/kg body weight per day for 10 days, subcutaueous) on the number and distribution of white blood cells (WBCs) were studied in male adult rats. The administration of DHC and CAP for 10 days decreased significantly the number of total WBCs, lymphocytes and monocyte, and increased significantly the number of the neutrophil and eosinophil without changing the number of basophil. The administration of DHC significantly decreased thymus weight and increased adrenal weight, showing that DHC induced thymus atrophy and adrenal hypertrophy. These results suggest that capsaicinoids induced the decrease of acquired immunity responses and these phenomena may have in part participated in capsaicinoids-induced stress-responses in rats.

    元の言語English
    ページ(範囲)99-103
    ページ数5
    ジャーナルJournal of Health Science
    56
    発行部数1
    DOI
    出版物ステータスPublished - 2010 2

    ASJC Scopus subject areas

    • Toxicology
    • Health, Toxicology and Mutagenesis

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    Aritoshi, S., Sato, S., Kumazawa, M., Ban, T., Tanihata, J., Tachiyashiki, K., & Imaizumi, K. (2010). Subacute effects of capsaicinoids on the distribution of white blood cells in rats. Journal of Health Science, 56(1), 99-103. https://doi.org/10.1248/jhs.56.99