Substrate specificity of thermostable D-alanine-D-alanine ligase from Thermotoga maritima ATCC 43589

研究成果: Article査読

7 被引用数 (Scopus)

抄録

D-Alanine-D-alanine ligase (Ddl) and its mutants maintain the biosynthesis of peptidoglycan, and the substrate specificity of Ddls partially affects the resistance mechanism of vancomycin-resistant enterococci. Through investigation of Ddls, Ddl from Thermotoga maritima ATCC 43589 showed novel characteristics, vis. thermostability up to 90°C and broad substrate specificity toward 15 D-amino acids, particularly D-alanine, D-cysteine, and D-serine, in that order.

本文言語English
ページ(範囲)2790-2792
ページ数3
ジャーナルBioscience, Biotechnology and Biochemistry
70
11
DOI
出版ステータスPublished - 2006

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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