TY - JOUR
T1 - Sugar-Derived Poly(β-thioester)s as a Biomedical Scaffold
AU - Moon, Nicholas G.
AU - Mazzini, Fiorella
AU - Pekkanen, Allison M.
AU - Wilts, Emily M.
AU - Long, Timothy Edward
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The monomer isosorbide diacrylate (iSDA) and commercially available dithiols allowed access to a range of biosourced, degradable polymers. Altering the dithiol identity significantly affected the glass transition Tgs of the polymer products; however, polymers did not exhibit Tgs above room temperature. Incorporating the comonomer N,N'-methylene bisacrylamide provided mechanical reinforcement through hydrogen bonding, resulting in soft, pliable materials. Differential scannin calorimetry (DSC) and variable-temperature fourier-transform infrared (FTIR) spectroscopy indicated that increases in mechanical integrity resulted from hydrogen bonding. Dynamic mechanical analysis (DMA) revealed materials that exhibited suitable moduli and service windows at body temperature. Biological evaluation demonstrated favorable cytotoxicity and cell attachment, rendering these materials potential candidates as novel scaffold materials for tissue growth.
AB - The monomer isosorbide diacrylate (iSDA) and commercially available dithiols allowed access to a range of biosourced, degradable polymers. Altering the dithiol identity significantly affected the glass transition Tgs of the polymer products; however, polymers did not exhibit Tgs above room temperature. Incorporating the comonomer N,N'-methylene bisacrylamide provided mechanical reinforcement through hydrogen bonding, resulting in soft, pliable materials. Differential scannin calorimetry (DSC) and variable-temperature fourier-transform infrared (FTIR) spectroscopy indicated that increases in mechanical integrity resulted from hydrogen bonding. Dynamic mechanical analysis (DMA) revealed materials that exhibited suitable moduli and service windows at body temperature. Biological evaluation demonstrated favorable cytotoxicity and cell attachment, rendering these materials potential candidates as novel scaffold materials for tissue growth.
KW - Biomaterial
KW - Isosorbide
KW - Poly(β-thioester)
KW - Renewable feedstock
KW - Thiol-michael
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U2 - 10.1002/macp.201800177
DO - 10.1002/macp.201800177
M3 - Article
AN - SCOPUS:85050719571
JO - Macromolecular Chemistry and Physics
JF - Macromolecular Chemistry and Physics
SN - 1022-1352
ER -