Sugar-Derived Poly(β-thioester)s as a Biomedical Scaffold

Nicholas G. Moon, Fiorella Mazzini, Allison M. Pekkanen, Emily M. Wilts, Timothy Edward Long*

*この研究の対応する著者

研究成果査読

7 被引用数 (Scopus)

抄録

The monomer isosorbide diacrylate (iSDA) and commercially available dithiols allowed access to a range of biosourced, degradable polymers. Altering the dithiol identity significantly affected the glass transition Tgs of the polymer products; however, polymers did not exhibit Tgs above room temperature. Incorporating the comonomer N,N'-methylene bisacrylamide provided mechanical reinforcement through hydrogen bonding, resulting in soft, pliable materials. Differential scannin calorimetry (DSC) and variable-temperature fourier-transform infrared (FTIR) spectroscopy indicated that increases in mechanical integrity resulted from hydrogen bonding. Dynamic mechanical analysis (DMA) revealed materials that exhibited suitable moduli and service windows at body temperature. Biological evaluation demonstrated favorable cytotoxicity and cell attachment, rendering these materials potential candidates as novel scaffold materials for tissue growth.

本文言語English
ジャーナルMacromolecular Chemistry and Physics
DOI
出版ステータスAccepted/In press - 2018 1 1
外部発表はい

ASJC Scopus subject areas

  • 凝縮系物理学
  • 物理化学および理論化学
  • ポリマーおよびプラスチック
  • 有機化学
  • 材料化学

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