Support mechanism of a newly-designed mechanical artificial myocardium using shape memory alloy fibres

Yasuyuki Shiraishi, T. Yambe, S. Itoh, R. Sakata, Y. Wada, K. Sekine, Y. Saijo, S. Konno, S. Nitta, Q. Wang, H. Liu, M. Higa, Y. Luo, D. Ogawa, A. Tanaka, M. Yoshizawa, Y. Kakubari, H. Miura, F. Sato, H. MatsukiM. Uematsu, Y. Park, T. Tanaka, M. Umezu, T. Fujimoto, N. Masumoto, Y. Hori, H. Sasada, K. Tabayashi, E. Okamoto, D. Homma

研究成果: Conference contribution

抄録

As the heart failure is caused by the decrease in the myocardial contraction, the direct mechanical myocardial assistance in response to physiological demand, that is, the synchronous support of the contractile function from outside of the heart, might be effective. The purpose of this study was to develop an artificial myocardium which was capable of supporting the cardiac contraction directly by using the shape memory alloy fibres based on nanotechnology. Some methodologies using novel devices other than the artificial hearts are proposed so far with severe heart disease. However, it was also anticipated that the decrease in cardiac functions owing to the diastolic disability might be caused by using those ‘static’ devices. Then, this study was focused on an artificial myocardium using shape memory alloy fibres with a diameter of 100 – 150 um, and the authors examined its mechanism in a mock circulatory system as well as in animal experiments using goats. Basic characteristics of the material were evaluated prior to the hydrodynamic or hemodynamic examination using a mock ventricular model. The results were as follows: a) The length of the structure was able to be adjusted so that the system could wrap the whole heart effectively. b) In the hydrodynamic study using the mock circulatory system, the myocardial system was able to pump a flow against the afterload of arterial pressure level. c) In the animal experiments, aortic pressure and flow rate were elevated by 7 and 15% respectively by the mechanical assistance of the artificial myocardium, which was driven synchronising with the electrocardiogram, and also, d) The anatomically-identical shape of the artificial myocardium might be more effective for the assistance. In conclusion, it was indicated that this controllable artificial myocardial support system was effective for the mechanical cardiac support for the chronic heart failure.

本文言語English
ホスト出版物のタイトルIFMBE Proceedings
編集者Sun I. Kim, Tae Suk Suh
出版社Springer Verlag
ページ3161-3164
ページ数4
1
ISBN(印刷版)9783540368397
DOI
出版ステータスPublished - 2007
イベント10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 - Seoul, Korea, Republic of
継続期間: 2006 8 272006 9 1

出版物シリーズ

名前IFMBE Proceedings
番号1
14
ISSN(印刷版)1680-0737
ISSN(電子版)1433-9277

Other

Other10th World Congress on Medical Physics and Biomedical Engineering, WC 2006
CountryKorea, Republic of
CitySeoul
Period06/8/2706/9/1

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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