抄録
Osteoporosis is a serious health problem for postmenopausal women and the elderly. We have focused our research on the bioactive substances from mushrooms to help cure osteoporosis by suppressing the formation of osteoclasts. In this study, two sterols were isolated from an edible mushroom Leccinum extremiorientale. The structures of 1 and 2 were identified by spectroscopic analysis. Compounds 1 and 2 showed the ability to suppress the formation of osteoclasts. This is the first report of the isolation of the compounds from the genus Leccinum and of the inhibitory activity of these compounds against the formation of osteoclasts.
本文言語 | English |
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ページ(範囲) | 401-406 |
ページ数 | 6 |
ジャーナル | International Journal of Medicinal Mushrooms |
巻 | 12 |
号 | 4 |
出版ステータス | Published - 2010 |
外部発表 | はい |
ASJC Scopus subject areas
- 応用微生物学とバイオテクノロジー
- 創薬
- 薬理学