Suppressing the formation of osteoclasts using bioactive components of the edible mushroom Leccinum extremiorientale (L. Vass.) singer (Agaricomycetideae)

Jae Hoon Choi, Nobuhiko Ozawa, Kikuko Masuda, Tomoyuki Koyama, Kazunaga Yazawa, Hirokazu Kawagishi*

*この研究の対応する著者

研究成果査読

7 被引用数 (Scopus)

抄録

Osteoporosis is a serious health problem for postmenopausal women and the elderly. We have focused our research on the bioactive substances from mushrooms to help cure osteoporosis by suppressing the formation of osteoclasts. In this study, two sterols were isolated from an edible mushroom Leccinum extremiorientale. The structures of 1 and 2 were identified by spectroscopic analysis. Compounds 1 and 2 showed the ability to suppress the formation of osteoclasts. This is the first report of the isolation of the compounds from the genus Leccinum and of the inhibitory activity of these compounds against the formation of osteoclasts.

本文言語English
ページ(範囲)401-406
ページ数6
ジャーナルInternational Journal of Medicinal Mushrooms
12
4
出版ステータスPublished - 2010
外部発表はい

ASJC Scopus subject areas

  • 応用微生物学とバイオテクノロジー
  • 創薬
  • 薬理学

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