Suppressive effects of Anoectochilus formosanus extract on osteoclast formation in vitro and bone resorption in vivo

Kikuko Masuda, Mayumi Ikeuchi, Tomoyuki Koyama, Kohji Yamaguchi, Je Tae Woo, Tomio Nishimura, Kazunaga Yazawa*

*この研究の対応する著者

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Anoectochilus formosanus, a plant native to Taiwan, is used as a folk medicine. It was found that oral administration of A. formosanus extract (AFE) (500 mg/kg) for 4 weeks suppressed bone weight loss and trabecular bone loss in ovariectomized mice, an experimental model of osteoporosis. Although AFE at 12.5 and 25 μg/ml inhibited osteoclast formation in co-culture of osteoblasts and bone marrow cells, AFE did not inhibit the formation of osteoclast progenitor cells and preosteoclast cells in bone marrow cells and RAW264 cells. However, AFE (at 12.5 and 25 μg/ml) decreased RANKL expression. These results suggested that AFE might suppress the bone loss caused by estrogen deficiency through suppression of RANKL expression required for osteoclast formation.

本文言語English
ページ(範囲)123-129
ページ数7
ジャーナルJournal of Bone and Mineral Metabolism
26
2
DOI
出版ステータスPublished - 2008 3月
外部発表はい

ASJC Scopus subject areas

  • 内分泌学

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