Surface modification of magnetic nanoparticles using asparagines-serine polypeptide designed to control interactions with cell surfaces

Masayuki Takahashi, Tomoko Yoshino, Tadashi Matsunaga

研究成果: Article査読

27 被引用数 (Scopus)

抄録

Surface modification is an important part of the fabrication of nanoparticles that have specific properties and functions. Here we describe the development of a functional polypeptide and a simple available technology for surface modification of nanoparticles. A NS polypeptide, which is 100 amino acids composed of repeated units of four asparagine and one serine residue (NS), as a molecule for nanoparticle surface modification was designed. Modification of the surface of a magnetic nanoparticle with the NS polypeptide results in reduction of particle-particle and particle-cell interactions. When NS polypeptide is used in single fusion protein as a linker to display protein G on nanoparticles, the nanoparticle acquires the capacity to specifically bind target cells and to avoid nonspecific adsorption of non-target cells. This technology, incorporating a functional polypeptide, may represent a completely new strategy for surface modification of nanoparticles for use in a variety of cell-associated applications.

本文言語English
ページ(範囲)4952-4957
ページ数6
ジャーナルBiomaterials
31
18
DOI
出版ステータスPublished - 2010 6
外部発表はい

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

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