Surgical timing prediction of patient-specific congenital tracheal stenosis with bridging bronchus by using computational aerodynamics

Juanya Shen, Limin Zhu, Zhirong Tong, Jinfen Liu, Mitsuo Umezu, Zhuomin Xu, Jinlong Liu

    研究成果: Conference contribution

    2 被引用数 (Scopus)

    抄録

    Congenital tracheal stenosis (CTS) has a high clinical mortality in neonates and infants. Although the procedure of slide tracheoplasty (STP) applied over the years, it is still a challenge for clinicians to predict the surgical timing of the CTS correction. In the present study, we studied on three-dimensional (3D) aerodynamic analysis of an original tracheal model from a specific patient with CTS and bridging bronchus (BB) and four new reconstructed models. We constructed a 3D patient-specific tracheal model based on CT images and applied computer-aided design (CAD) to reconstruct four models to imitate the stenosis development of CTS. Average pressure drop (APD), wall shear stress (WSS) and velocity streamlines were calculated to analyze local aerodynamic characteristics for the evaluation of airflow at the inspiration phase and expiration phase, respectively. We found APD, WSS and AEL decreased during the respiration with the decrease of stenosis. Three abnormal gradients in APD were observed between the main stenosis of trachea arrived at 80% and 60%. This implied the surgical correction may be required when the main stenosis reached 60%. The combination of CAD and aerodynamic analysis is a potential noninvasive tool for surgical timing prediction in the management of patient-specific correction of CTS.

    本文言語English
    ホスト出版物のタイトルAdvanced Computational Methods in Life System Modeling and Simulation - International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, Proceedings
    出版社Springer Verlag
    ページ181-190
    ページ数10
    761
    ISBN(印刷版)9789811063695
    DOI
    出版ステータスPublished - 2017
    イベントInternational Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017 - Nanjing, China
    継続期間: 2017 9 222017 9 24

    出版物シリーズ

    名前Communications in Computer and Information Science
    761
    ISSN(印刷版)1865-0929

    Other

    OtherInternational Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017
    CountryChina
    CityNanjing
    Period17/9/2217/9/24

    ASJC Scopus subject areas

    • Computer Science(all)
    • Mathematics(all)

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