Switching of the surface function of liposomes modified with poly(ethylene glycol)-lipids

Kohei Kubota, Yosuke Okamura, Shinji Takeoka

研究成果: Paper査読

抄録

Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.

本文言語English
ページ4939-4940
ページ数2
出版ステータスPublished - 2005 12 1
イベント54th SPSJ Symposium on Macromolecules - Yamagata, Japan
継続期間: 2005 9 202005 9 22

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period05/9/2005/9/22

ASJC Scopus subject areas

  • Engineering(all)

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