Symptom profile of multiple chemical sensitivity in actual life

Mariko Saito, Hiroaki Kumano*, Kazuhiro Yoshiuchi, Naomi Kokubo, Kyoko Ohashi, Yoshiharu Yamamoto, Naohide Shinohara, Yukio Yanagisawa, Kou Sakabe, Mikio Miyata, Satoshi Ishikawa, Tomifusa Kuboki

*この研究の対応する著者

研究成果: Article査読

40 被引用数 (Scopus)

抄録

Objective: This study was conducted to confirm the definition of multiple chemical sensitivity (MCS) in actual life: that multiple symptoms are provoked in multiple organs by exposure to, and ameliorated by avoidance of, multiple chemicals at low levels. We used the Ecological Momentary Assessment to monitor everyday symptoms and the active sampling and passive sampling methods to measure environmental chemical exposure. Methods: Eighteen patients with MCS, diagnosed according to the 1999 consensus criteria, and 12 healthy controls participated in this study. Fourteen patients and 12 controls underwent 1-week measurement of physical and psychologic symptoms and of the levels of exposure to various chemicals. Linear mixed models were used to test the hypotheses regarding the symptom profile of MCS patients. Results: Some causative chemicals were detected in 11 of 14 MCS patients. Two other patients did not report any hypersensitivity episodes, whereas passive sampling showed far less exposure to chemicals than control subjects. Another subject reported episodic symptoms but was excluded from the following analyses because no possible chemical was detected. Eleven of the 17 physical symptoms and all four mood subscales examined were significantly aggravated in the interview based on "patient-initiated symptom prompts." On the other hand, there were no differences in physical symptoms or mood subscales between MCS patients and control subjects in the interview based on "random prompts." Conclusions: MCS patients do not have either somatic or psychologic symptoms under chemical-free conditions, and symptoms may be provoked only when exposed to chemicals.

本文言語English
ページ(範囲)318-325
ページ数8
ジャーナルPsychosomatic Medicine
67
2
DOI
出版ステータスPublished - 2005 3月
外部発表はい

ASJC Scopus subject areas

  • 応用心理学
  • 精神医学および精神衛生

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