Syn-selective kobayashi aldol reaction using acetals

Hiroyuki Tsukada, Yuki Mukaeda, Seijiro Hosokawa

    研究成果: Article

    22 引用 (Scopus)

    抄録

    The Kobayashi aldol reaction has been used to construct anti-aldol products by remote stereoinduction. Since the product of the Kobayashi aldol reaction has a typical polyketide structure, this reaction has been applied to the total synthesis of natural products. By varying this reaction, it was found that the reaction with acetals in the presence of Lewis acid proceeded to give syn adducts in high stereoselectivity. This is the first example of the stereoselective reaction of the chiral dienol ether and acetals.

    元の言語English
    ページ(範囲)678-681
    ページ数4
    ジャーナルOrganic Letters
    15
    発行部数3
    DOI
    出版物ステータスPublished - 2013 2 1

    Fingerprint

    acetals
    Acetals
    Polyketides
    Stereoselectivity
    Lewis Acids
    Biological Products
    Ether
    products
    adducts
    3-hydroxybutanal
    ethers
    acids
    synthesis

    ASJC Scopus subject areas

    • Organic Chemistry
    • Physical and Theoretical Chemistry
    • Biochemistry

    これを引用

    Syn-selective kobayashi aldol reaction using acetals. / Tsukada, Hiroyuki; Mukaeda, Yuki; Hosokawa, Seijiro.

    :: Organic Letters, 巻 15, 番号 3, 01.02.2013, p. 678-681.

    研究成果: Article

    Tsukada, Hiroyuki ; Mukaeda, Yuki ; Hosokawa, Seijiro. / Syn-selective kobayashi aldol reaction using acetals. :: Organic Letters. 2013 ; 巻 15, 番号 3. pp. 678-681.
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