Syn-selective kobayashi aldol reaction using acetals

Hiroyuki Tsukada, Yuki Mukaeda, Seijiro Hosokawa*

*この研究の対応する著者

研究成果査読

27 被引用数 (Scopus)

抄録

The Kobayashi aldol reaction has been used to construct anti-aldol products by remote stereoinduction. Since the product of the Kobayashi aldol reaction has a typical polyketide structure, this reaction has been applied to the total synthesis of natural products. By varying this reaction, it was found that the reaction with acetals in the presence of Lewis acid proceeded to give syn adducts in high stereoselectivity. This is the first example of the stereoselective reaction of the chiral dienol ether and acetals.

本文言語English
ページ(範囲)678-681
ページ数4
ジャーナルOrganic Letters
15
3
DOI
出版ステータスPublished - 2013 2 1

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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